This study presents an integrated study combining global proteomics, lactylome, and genome-wide RNA sequencing to elucidate the role of lactylation throughout postnatal heart development. They demonstrate a remarkable increase in non-histone lactylation levels as early from 1 week (1 w) to 6 weeks (6 w) postpartum and remained elevated from 6 months (6 m) onwards. However, the histone lactylation showed the opposite trend.In particular, histone 4 lysine 12 lactylation (H4K12la) acts as a pivotal upstream regulatory element in the early postnatal mouse heart, from 1 w to 6 w postpartum. These findings strongly suggest a significant connection between lactylation and postnatal cardiac development and highlight its involvement in gene expression regulation, thus offering potential mechanisms for targeting heart diseases.

A study in Forest Ecosystems predicts that China’s natural forests will store 10.46 Pg C by 2060, but their carbon sequestration rate will decline as mature. Using satellite data and field surveys, researchers found that younger natural forests have higher carbon storage potential, while older natural forests are reaching their limit. The findings highlight the need to prioritize protecting mature forests alongside preserving and restoring young natural forest areas to sustain China’s high carbon sequestration capacity.

A new study unveils an innovative strategy to combat Pseudomonas aeruginosa, a major culprit behind food spoilage and foodborne illnesses. With antimicrobial resistance on the rise, conventional treatments are losing their effectiveness, creating an urgent need for alternative solutions. This research focuses on quorum sensing inhibitors (QSIs), which disrupt bacterial communication, reducing virulence and combating drug resistance. Unlike traditional antibiotics, QSIs do not kill bacteria, thus minimizing the risk of resistance development. The study evaluates a variety of QSIs, from natural compounds to enzymes, offering a fresh perspective on controlling this harmful pathogen.

A new study has revealed that ferulic acid, a natural compound found in various plant-based foods, can significantly inhibit the growth and migration of colon cancer cells at different stages of progression. The research, which offers valuable insights into how ferulic acid induces cell cycle arrest and apoptosis, suggests that this compound could serve as an effective dietary intervention for preventing colon cancer. These findings open new avenues for dietary strategies aimed at reducing the burden of this widespread disease.

In a bid to explore MAX phases with experimental significance across a significantly broader combinatorial space, the researchers of this study pioneered the development of a machine-learning model for predicting MAX phase stability. This model is based on elemental features and can swiftly forecast the stability of MAX phases by simply leveraging the basic parameters of elements. Notably, the model successfully identified 150 MAX phases that met the stability criteria but had not been synthesized previously. It also guided the first-ever experimental synthesis of Ti₂SnN. Ti₂SnN showcases a low elastic modulus, high damage tolerance, and self-extrusion characteristics. This accomplishment not only enhances the screening efficiency by a factor of tens but also uncovers the crucial role of valence electrons. As a result, it provides novel insights into the fundamental principles governing MAX phase formation.

Imbibition plays a crucial role in the stages of volumetric fracturing and water injection development in shale reservoirs. Due to their unique structure and properties, clay minerals have a profound impact on shale imbibition, thereby influencing the production of shale oil and gas. Understanding how clay minerals influence the process is essential for optimizing reservoir performance and improving recovery rates.

This review aims to provide a holistic understanding of BFO’s piezocatalytic potential, establishing its role in advancing sustainable catalytic technologies. By presenting a comprehensive overview of BFO’s development, performance, and applications, this manuscript will serve as a critical resource for researchers in the fields of materials science, catalysis, and sustainable technology.

Researchers from South Chian University of Technology have made a significant advancement in the field of water-based adhesives by developing a novel nanocomposite material that combines polyvinyl alcohol (PVA) with 1-nm Keggin-type polyoxotungstate clusters (POTs) carrying four negative charges. This innovative POT-PVA nanocomposite offers a promising solution for creating eco-friendly, versatile, and durable water-based adhesives suitable for a wide range of applications across various industries.